Gelam Honey Inhibits the Production of Proinflammatory

22 Feb

Gelam Honey Inhibits the Production of Proinflammatory

Natural honey is well known for its therapeutic value and has been used in traditional medicine of different cultures throughout the world. The aim of this study was to investigate the anti-inflammatory effect of Malaysian Gelam honey in inflammation-induced rats.

Inflammation is a complex biological response of the body to cell damage and vascularized tissue, which can be classified as either acute or chronic depending on the time of onset. Acute inflammation is the body’s primary response to injurious stimuli, and some of the body’s responses are characterized by pain, heat, redness, swelling, and loss of function. During an inflammatory response, several proinflammatory mediators are released.

From ancient times until now, several natural products and their derived formulations have been used in therapeutic applications for inflammatory disorders and related diseases. Curcumin was effective at preventing acute liver damage indicated by the reduced expression of proinflammatory cytokines and the deactivation of NFκB in an animal model study. Ginger extract has a potent anti-inflammatory property by inhibiting the production of proinflammatory mediators.

Honey is a natural product of honey bees, that is, derived from floral nectars and other plant secretions. Honey is rich in carbohydrates, proteins, vitamins, trace elements, enzymes, and phenolic compounds. Since archaic times, honey has been used as an ingredient of traditional medicine because of its dietary and curative properties. Scientific studies over the past ten years have shown that honey possesses various important biological properties, such as wound healing and antibacterial, antioxidant, antitumor, and anti-inflammatory effects.

In Malaysia, there are several types of honey, including Tualang, Nenas, Coconut, and Gelam. Among these, Tualang and Gelam honeys are well known in Malaysia for their potential health benefits, such as antioxidant and anti-inflammatory activities. Tualang honey contains highly phenolic compounds that possess relatively good antioxidant activity. In an animal model, a topical dressing of Tualang honey showed a positive effect for treating full-thickness burn wounds. We have previously reported that Gelam honey has antioxidative and radical scavenging activities, which are mainly attributed to its phenolic content. Other biological activities of Gelam honey that have been reported are wound healing, anti-inflammatory effects, and antioxidant activity.

In the present study, we investigated the anti-inflammatory activity of Gelam honey in short and long durations of treatments in rats that were induced with paw edema.

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